Presentations

“Next Generation Sequencing Reveals Genomic Heterogenity of ALK Fusion Breakpoints in Non-Small Cell Lung Cancer,” Poster Presentation, 2016 AMP Annual Meeting, Charlotte, NC

“Next Generation Sequencing Reveals Genomic Heterogenity of ALK Fusion Breakpoints in Non-Small Cell Lung Cancer,” Platform Presentation, 2016 USCAP Annual Meeting, Seattle, WA

“Genomic Profiling of Neuroendocrine and Neuroepithelial Neoplasms by Targeted Next Generation Sequencing” Platform Presentation, 2016 USCAP Annual Meeting, Seattle, WA

“Actionable KIT Mutation in High-Grade Neuroendocrine Carcinoma,” Presentation, 2015 AMP Annual Meeting, Austin, TX

“INSM1 mRNA Expression Correlates With Functional Subtype in Neuroendocrine Neoplasms (NENs),” Poster, 2015 AMP Annual Meeting, Austin, TX

“Expression of the Neuroepithelial Marker INSM1 in Ewing Sarcoma and Other Small Round Cell Sarcomas” Poster, 2015 USCAP Annual Meeting, Boston,MA

“INSM1 Expression Correlates With Metastasis and Functional Hormone Production in Neuroendocrine Neoplasms” Poster, 2015 USCAP Annual Meeting, Boston,MA

“Whole Exome Sequencing of Angiosarcoma” Poster, 2014 AMP Annual Meeting, Washington, D.C.

“Pleuroparenchymal Fibroelastosis: A Report of the First Two Cases Diagnosed at Autopsy” Poster, 2014 CAP Annual Meeting, Chicago, IL

“INSM1: a Novel Immunohistochemical Marker for Neuroendocrine and Neuroepithelial Neoplasms,” Poster, 2014 USCAP Annual Meeting, San Diego, CA

“Whole Exome Sequencing of Angiosarcoma” Research presentation, 2014 Annual Michael N. Hart Research Day, Madison, WI

“The Neuroendocrine Developmental Transcription Factor INSM1 is Overexpressed in Gastrointestinal Neuroendocrine Tumors” Poster, 2013 AMP Annual Meeting, Phoenix, AZ

“Who, What, Where, Wiki: Social media and crowd-sourcing effectively disseminate and preserve resident community knowledge,” Poster, 2013 ASCP Annual Meeting, Chicago, IL

“INSM1 as a marker of malignancy in neuroendocrine and neuroepithelial cancer” Research presentation, 2013 Annual Michael N. Hart Research Day, Madison, WI

“INSM1 as a marker for neuroendocrine cancer” Research presentation, 2012 Annual Michael N. Hart Research Day, Madison, WI

“Significantly Higher Expression Levels of Androgen Receptor Are Associated With Erythroblastosis Virus E26 Oncogene Related Gene Positive Prostate Cancer” Poster presentation, 2012 USCAP annual meeting, Vancouver, B.C.

“IA-1 in the development of the olfactory epithelium” Seminar, Cell and Molecular Neurology group meeting, Northwestern University, 2009

“Transient expression from late progenitor to neuron of the conserved zinc finger gene IA-1 during embryonic and adult neurogenesis” Poster, 2008 Mouse Genetics Group Meeting, Center for Genetic Medicine, Northwestern University

“Transient expression from late progenitor to neuron of the conserved zinc finger gene IA-1 during embryonic and adult neurogenesis” Poster, 2007 Society for Neuroscience Annual Meeting

“Transient expression from late progenitor to neuron of the conserved zinc finger gene IA-1 during embryonic and adult neurogenesis” Poster, Motor Day, 2007 Northwestern University Feinberg School of Medicine

“Pax-3 in Xenopus neural crest development” Seminar, 2004 Northwestern University MSTP Retreat

“Pax-3 and Pax-7 in Xenopus neural crest development” Poster Session, 2004 Northwestern University Integrated Biological Sciences Graduate Program Retreat

“Pax-3 and Pax-7 in Xenopus neural crest development” Poster Session, 2003 Northwestern University MSTP Retreat


Societies and Memberships

American Association for the Advancement of Science

American Medical Association

American Society for Clinical Oncology

American Society for Clinical Pathology

American Sociaty of Human Genetics

Association for Molecular Pathology

College of American Pathologists

Digital Pathology Society

Endocrine Pathology Society

United States and Canadian Academy of Pathology



Teaching

Wisconsin Center for Academically Talented Youth (WCATY), Human Body and Disease Course

Angevine Fellow (medical student summer internship in pathology) Lecture Series

Instructor, School of Cytotechnology, Wisconsin State Laboratory of Hygiene

Pathology 600 graduate course

Foundations of Medicine Instructor, University of Wisconsin School of Medicine and Public Health

Supervisor to Jennifer Ray, undergraduate research assistant in the laboratory of Dr. Jaime García-Añoveros

Teaching Assistant, Biochemistry. Dr. Andreas Matouschek and Dr. Neil Welker, Course Directors

Instructor and Curriculum Development, The Berkeley Review MCAT Preparation Course

Instructor and Course Design, English 198, University of California at Berkeley. Dr. Stephen Booth, Course Sponsor


Hobbies, Activities, and Interests

Writing (fiction, short non-fiction); comedy; competitive trivia

Improvisational acting and comedy training, Second City and improvOlympic, Chicago, IL

Writer, director, and performer of “In Vivo” Northwestern University School of Medicine’s annual variety show, donating proceeds to local charities

Performed with and directed “The Best Medicine,” Northwestern University School of Medicine’s improvisational comedy troupe  

Writer, The Heuristic Squelch, University of California at Berkeley humor magazine



Published Abstracts

Rosenbaum, JN, Branson, J, Cottrell, CE, Pfeifer, JD, Kulkarni, S, Duncavage EJ. Next Generation Sequencing Reveals Genomic Heterogeneity of ALK Fusion Breakpoints in Non-Small Cell Lung Cancer. Modern Pathology, 29 (S2) p.481A.  USCAP Annual Meeting 2016; March 12-19, 2016; Boston, MA. Nature Publishing Group.

Rosenbaum, JN
, Storer, C, Cottrell, CE, Duncavage EJ. Genomic Profiling of Neuroendocrine and Neuroepithelial Neoplasms by Targeted Next Generation Sequencing. Modern Pathology, 29 (S2) p.145A.  USCAP Annual Meeting 2016; March 12-19, 2016; Boston, MA. Nature Publishing Group.


Rosenbaum, JN,
Baus, RM, Rehrauer, WM, Lloyd, RV, INSM1 mRNA Expression Correlates With Metastasis and Functional Hormone Production in Neuroendocrine Neoplasms. Journal of Molecular Diagnostics, 17 (6), p.817; AMP Annual Meeting, 2015; Austin, TX.

​Rosenbaum, JN,
Baus, RM, Lloyd, RV, Buehler, DA, Expression of the Neuroepithelial Marker INSM1 in Ewing Sarcoma and Other Small Round Cell Sarcomas. Modern Pathology, 28 (S2) p.24A.  USCAP Annual Meeting, 2015; March 21-27, 2015; Boston, MA. Nature Publishing Group.

Rosenbaum, JN, Yang, R, Baus, RM, Rehrauer, WM, Huang, W, Lloyd, RV, INSM1 Expression Correlates With Metastasis and Functional Hormone Production in Neuroendocrine Neoplasms. Modern Pathology, 28 (S2) p.140A.USCAP Annual Meeting, 2015; March 21-27, 2015; Boston, MA. Nature Publishing Group. 

Rush, PS, Rosenbaum, JN, Baus, RM, Bennett, DD, Lloyd, RV, INSM1: A Novel Nuclear Marker in Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma). Modern Pathology, 28 (S2) p.125A. USCAP Annual Meeting, 2015; March 21-27, 2015; Boston, MA. Nature Publishing Group.

Rosenbaum, JN
, Accola, MA., Pavelec, DM., Laffin, JJ., Johnson, KA., Hasenstein, J., Kozak, KR., Rehrauer, WM., Buehler, D. Whole Exome Sequencing of Angiosarcoma Identifies Novel Variants. Journal of Molecular Diagnostics. Association for Molecular Pathology 2014 Annual Meeting; November 2014; Washington, DC. Elsevier; 2014. p.753. 

​Butt, YM, Rosenbaum, JN, Johnson, KA, Batra, K, Kanne, JP, Torrealba, JR. Pleuroparenchymal Fibroelastosis: A Report of the First 2 Cases Diagnosed at Autopsy. Archives of Pathology and Laboratory Medicine. College of American Pathologists 2014 Annual Meeting; September 6-11; Chicago, IL. p.e44. 

Rosenbaum, JN, Baus, RM, Werner, HS, Rehrauer, WM, Lloyd, RV. INSM1: A Novel Immunohistochemical Marker for Neuroendocrine and Neuroepithelial Neoplasms. Modern Pathology. USCAP Annual Meeting, 2014; March 1-7, 2014; San Diego, CA. Nature; 2014. p.158A. 

Rosenbaum, JN,Who, What, Where, Wiki: Social Media and Crowd Sourcing Effectively Disseminate and Preserve Resident Community Knowledge. American Journal of Clinical Pathology. American Society for Clinical Pathology; September 18-21, 2013; Chicago, IL. 2013. p.A210. 

Rosenbaum, JN, Baus, RM, Werner, HS, Rehrauer, WM, Lloyd, RV. The Neuroendocrine Developmental Transcription Factor INSM1 is Overexpressed in Gastrointestinal Neuroendocrine Tumors. Journal of Molecular Diagnostics. Association for Molecular Pathology 2013 Annual Meeting; November 14-16; Phoenix, AZ. Elsevier; 2013. p.906. 

Rosenbaum, J, Huang, W, Significantly Lower Expression Levels of Androgen Receptor (AR) Are Associated with Erythroblastosis Virus E26 Oncogene Related Gene (ERG) Negative (-) Prostate Cancer (PCa). #971. United States and Canadian Academy of Pathology’s 101st Annual Meeting; March 17-23, 2012; Vancouver, BC, Canada. 2012.

Rosenbaum, JN, Duggan, A, Madathany, T, DeCastro, SCP, Gerelli, D, Garcia-Anoveros, JG; “Transient expression from late progenitor to neuron of the conserved zinc finger gene INSM1 during embryonic and adult neurogenesis.” Program No. 816.16/B10. Neuroscience 2007 Abstracts. San Diego, CA: Society for Neuroscience, 2007. Online.


Bibliography

E. Duncavage, R. Advani, S. Agosti, P. Foulis, C. Gibson, L. Kang, J. Khoury, L. Medeiros, R. Ohgami, D. O’Malley, K. Patel, J. Rosenbaum, C. Wilson. (2016) Template for Reporting Results of Biomarker Testing of Specimens From Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Archives of Pathology and Laboratory Medicine, In Press. DOI
: http://dx.doi.org/10.5858/arpa.2016-0045-CP


E. Duncavage, R. Advani, S. Agosti, P. Foulis, C. Gibson, L. Kang, J. Khoury, L. Medeiros, R. Ohgami, D. O’Malley, K. Patel, J. Rosenbaum, C. Wilson. (2016) Template for Reporting Results of Biomarker Testing of Specimens From Patients With Diffuse Large B-Cell Lymphoma, Not Otherwise Specified. Archives of Pathology and Laboratory Medicine, In Press. DOI: http://dx.doi.org/10.5858/arpa.2015-0418-CP​

​J. Rosenbaum,
Z. Guo, R. Baus, H. Werner, W. Rehrauer, R. Lloyd. (2015) INSM1: a Novel Immunohistochemical and Molecular Marker for Neuroendocrine and Neuroepithelial Neoplasms. American Journal of Clinical Pathology, Oct;144(4): 579-591. PMID: 26386079

R. Lloyd, J. Rosenbaum, L. Erickson (2015). Immunohistochemical Approach to the Diagnosis and Prognostic Evaluation of Pancreatic Neuroendocrine Neoplasms. Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, Classification, and Therapy. S. La Rosa, F. Sessa (eds.) DOI 10.1007/978-3-319-17235-4_7

J. Rosenbaum, Y. Butt, K. Johnson, K. Meyer, K. Batra, J. Kanne, J. Torrealba. (2014) Pleuroparenchymal Fibroelastosis: a Pattern of Chronic Lung Injury. Human Pathology, 2015 Jan;46(1):137-46. PMID: 25454481

J. Rosenbaum, R. Lloyd. (2014) Pancreatic Neuroendocrine Neoplasms (Pan-NEN). Clinics Review Articles: Surgical Pathology Clinics. (7) 559–575. Available at: http://www.sciencedirect.com/science/article/pii/S1875918114000920​

J. Rosenbaum, S. Drew, W. Huang. (2014) Significantly Higher Expression Levels of Androgen Receptor Are Associated With Erythroblastosis Virus E26 Oncogene Related Gene Positive Prostate Cancer. American Journal of Clinical and Experimental Urology 2014;2(3):249-257. PMID: 25374927

J. Rosenbaum, A. Duggan, and J. García-Añoveros. (2011) Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminal and neuronogenic. Neural Development, February 1;6:6. PMID: 21284846

​J. Rosenbaum and K. Padian. (2000) New material of the basal Thyreophoran Scutellosaurus lawleri from the Kayenta Formation (Lower Jurassic) of Arizona. Paleobios 20 :13

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Curriculum Vitae

Click Here for PDF


JNRosenbaumMD@gmail.com

Center for Personalized Diagnostics

University of Pennsylvania, Perelman School of Medicine
3020 Market St.
Suite 220
Philadelphia, PA 19104

0: (215) 349-8456
c: (267) 586-2525
f: (844) 373-1882

Jason N. Rosenbaum, MD

Grants & Honors
Best Platform Presentation, Trainee Research Day, Washington University Department of Pathology and Immunology, 2016

Pilot Award, UWCCC Neuroendocrine Cancer Research Task Force and the Aly Wolff Memorial Fund for Neuroendocrine Carcinoma Research, 2015-2017

Michael N. Hart Research Day Resident Presentation Award, 2014

​ICPI Travel Grant, USCAP Annual Meeting, 2014

University of Wisconsin Research and Development Grant, 2011-2015

Best Poster Finalist, Education Category, American Society for Clinical Pathology Annual Meeting, Chicago, 2013

University of Wisconsin Hospital and Clinics Quality Improvement Award, 2013

Michael N. Hart Research Day Resident Presentation Award, 2012

Morton Heller Award for Exemplary Research, 2010

BA, High Honors in Integrative Biology, 1998

UC Berkeley Chancellor’s Scholar

​National Merit Scholar

Education & Training

Molecular and Genetic Pathology Fellowship

Washington University, Barnes Jewish Hospital


Diplomate, Anatomic and Clinical Pathology, The American Board of Pathology


Residency Training, Anatomic and Clinical Pathology
University of Wisconsin Hospital and Clinics


Doctor of Medicine,
Northwestern University Feinberg School of Medicine


BA (Honors), Molecular and Cell Biology/Integrative Biology, Creative Writing minor
University of California at Berkeley, Berkeley, CA

Leadership

Section Editor for Precision Medicine, Archives of Pathology & Laboratory Medicine, 2016 - present


Ambassador, United States and Canada Academy of Pathology, 2016 - present


Engaged Leadership Academy, College of American Pathologists, 2016 - present


Junior member, College of American Pathologists Committee on Cancer Biomarker Reporting, 2015-2016


Participated in validation of microbial identification from blood cultures using  MALDI-TOF, 2014

Founded and administered UW Pathology Resident Research Interest Group

Streamlined paperwork on UWHC autopsy service

Resident Delegate to the College of American Pathologists 2011-2014Founded and managed UWHC


Department of Pathology and Laboratory Medicine Residency Program Wiki

Member of Northwestern University Medical School’s curriculum committee

Founded Dura Mater, Northwestern University Medical School’s first humor magazine

Editor-in-Chief, The Heuristic Squelch, University of California at Berkeley humor magazine

Research Experience


2015 - present: Self-Directed Research with Eric Duncavage, MD

Department of Pathology and Immunology, Washington University, Barnes Jewish Hospital

  1. Use of Next Generation Sequencing to Detects Novel ALK gene Rearrangements and Predict Therapeutic Response in Non-Small Cell Lung Cancer
  2. Genomic Landscape of Somatic Variants in Neuroendocrine Carcinoma


2014 - present: Research with Darya Buehler, MD, William Rehrauer, PhD, and Jennifer Laffin, PhD Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics 

Whole Exome Sequencing of Angiosarcoma


2011 - present:  Self-directed research with Ricardo V. Lloyd, MD, PhD and William Rehrauer, PhD

Translational Research Initiatives in Pathology (TRIP) Laboratory

Department of Pathology and Laboratory Medicine University of Wisconsin Hospital and Clinics

  1. Insm1 as a marker for human neuroendocrine and neuroepithelial cancer (IRB approved and funded by Departmental R&D Grant).
  2. Identification of novel prognostic and therapeutic targets in neuroendocrine neoplasms using multivariate correlation of molecular, phenotypic, and clinical behavior (funded by UW Carbone Cancer Center Grant)


2006 - 2010: Research under Jaime García-Añoveros, Ph.D.
Department of Anesthesiology
Northwestern University
INSM-1 and INSM2 in mammalian neural development and evolution.

2002 - 2004: Research under Carole LaBonne, Ph.D.Department of Biochemistry, Molecular Biology, and Cell Biology
Northwestern University
Pax-3 and Pax-7 transcription factors in Xenopus neural crest development.

1998 - 2000: Research Assistant to Kevin Padian, Ph.D.
Department of Integrative Biology, University of California at Berkeley
New material of the basal Thyreophoran Scutellosaurus lawleri from the Kayenta Formation (Lower  Jurassic) of Arizona.